Pharmacological interventions may also be based on natural products and their use has grown in popularity amongst pet owners and veterinarians . Lavender ( Lavandula angustifolia ) and chamomile ( Anthennis nobilis ) have been reported to produce a calming effect by increasing behaviours indicative of relaxation (e.g., resting and sleeping) and also reducing barking in dogs housed in rescue shelters . Pet Remedy (Unex Designs Ltd., Torquay, Devon, UK) is a commercial pharmacological intervention based on the herb valerian ( Valeriana officinalis ). Valerian has been shown to have anxiety reducing properties in humans [33,34], perhaps by enhancing production  or impeding breakdown  of the inhibitory neurotransmitter GABA (Gamma Amino Butyric Acid). This may occur because GABA receptors (at least in rodents) have an affinity with valerinic acid and valerinol [35,37,38].
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