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Pharmacological interventions may also be based on natural products and their use has grown in popularity amongst pet owners and veterinarians [31]. Lavender ( Lavandula angustifolia ) and chamomile ( Anthennis nobilis ) have been reported to produce a calming effect by increasing behaviours indicative of relaxation (e.g., resting and sleeping) and also reducing barking in dogs housed in rescue shelters [32]. Pet Remedy (Unex Designs Ltd., Torquay, Devon, UK) is a commercial pharmacological intervention based on the herb valerian ( Valeriana officinalis ). Valerian has been shown to have anxiety reducing properties in humans [33,34], perhaps by enhancing production [35] or impeding breakdown [36] of the inhibitory neurotransmitter GABA (Gamma Amino Butyric Acid). This may occur because GABA receptors (at least in rodents) have an affinity with valerinic acid and valerinol [35,37,38].

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