does cbd oil interact with methotrexate

Drugs that May Interact with CBD Oil

Drugs that May Interact with CBD Oil

CBD oil interacts with certain prescription medications, which is why you should always consult your doctor before using cannabidiol.

CBD Oil Drug Interactions – The CYP450 Pathway

Research has begun to demonstrate that cannabidiol (CBD) has the potential to effectively help a large number of people. CBD oil interacts with the endocannabinoid system in a way that produces very few unintended side-effects.

While the majority of the vast majority of the science indicates CBD oil is safe for use and consumption, it does pose a few risks that, if not properly understood, could be dangerous.

One of these risks is the inhibition of the cytochrome P450 enzyme system .

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What is the Cytochrome P-450 System?

Found within the liver, the cytochrome P450 enzyme system is responsible for metabolizing potentially toxic compounds, including over 60% percent of any drugs you have consumed.

According to Davis’s Drug Guide, this system contains more than 50 enzymes that process and eliminate toxins.

Why Does CYP450 Matter?

In order to determine the appropriate dosages of medications, doctors make calculations using the average amount of time it takes for various drugs and medications to be processed through the cytochrome P450 system.

If only one drug is being processed, and the system is generally healthy, these averages provide accurate dosage information.

However, certain substances have the ability to affect processing times within this system, making drugs metabolize faster or slower than they would on their own.

Similarly, if the cytochrome P450 system is unhealthy due to problems with the liver or other pre-existing conditions, drugs may not metabolize as they should.

Cannabidiol in the Cytochrome P-450 System

Cannabidiol can inhibit the cytochrome P450 system’s ability to metabolize certain drugs, leading to an overall increase in processing times.

Interestingly, CBD oil is not alone in its effect on drug metabolism. Grapefruit , watercress , St. John’s Wort , and goldenseal all have a similar impact in terms of CYP450 inhibition.

When the CYP450 system is impacted in this way, it leads to higher levels of certain drugs in your system at one time. This can cause unwanted side effects, and sometimes, an overdose.

If you are taking a medication affected by cannabidiol, you should consult your doctor to make sure that it is safe for you to supplement your personal care routine with CBD oil. From there, the two of you may consider adjusting the dosage on your medications so that you can use both products safely.

Drugs that Interact with Cannabidiol

Any drug metabolized by CYP450 enzymes could potentially interact with cannabidiol. According to the Indiana University Department of Medicine , drugs known to use the CYP450 system include:

  • Steroids
  • HMG CoA reductase inhibitors
  • Calcium channel blockers
  • Antihistamines
  • Prokinetics
  • HIV antivirals
  • Immune modulators
  • Benzodiazepines
  • Antiarrythmics
  • Antibiotics
  • Anesthetics
  • Antipsychotics
  • Antidepressants
  • Anti-epileptics
  • Beta blockers
  • PPIs
  • NSAIDs
  • Angiotension II blockers
  • Oral hypoglycemic agents
  • Sulfonylureas

This list does not include all of the potential medications impacted by cannabidiol. Nor will every medication in the categories contained on this list will cause an interaction. For these reasons, you should consult with a medical professional before supplementing with CBD oil.

There are certain medications, known as “prodrugs,” that need to be metabolized to produce the therapeutic compound. In other words, you ingest an inactive compound and once in the body, it is processed into the active drug. If this processing is dependent on CYP3A4 (part of the larger CYP450 system), then inhibitors can result in too little active drug in the body for the desired therapeutic effect.

Codeine , for example, is a prodrug that is metabolized into morphine which provides the effect.

Vyvanse and Concerta are two other popular pharmaceutical medications for ADHD that fall into this category.

If you are worried that your CYP450 pathway may not be functioning properly, physicians can test the system to ensure that the medications you take are metabolizing as expected.

Combining Alcohol and CBD Oil

Alcohol and cannabis are both widely consumed in our society and the effects of combining the two are well known.

What is less understood by the general public, is the effects of combining alcohol and the cannabinoid compound CBD.

Alcohol depends on a few different metabolic pathways in the human body, with the primary enzymes involved being:

In people who only drink socially or occasionally, ADH and ALDH handle the entire workload of metabolizing ethanol. However, when binge drinking (or during chronic consumption of alcohol) CYP450 gets involved to assist the overloaded ADH and ALDH pathways.

Here are some interesting tidbits about alcohol and CBD oil:

  • The CB1 receptor is a significant player in the reinforcing and motivating attributes of alcohol. [ S ]
  • Combining alcohol and CBD results in significantly lower blood levels of alcohol. [ S ]
  • CBD reduces the reinforcement, motivation and relapse for alcohol. [ S ]
  • CBD protects the liver from damage done by binge-drinking alcohol. [ S ]
  • CBD prevents against alcohol-induced neurodegeneration. [ S ]
  • CBD attenuates alcohol-induced liver steatosis, metabolic dysregulation, inflammation and neutrophil-mediated injury. [ S ]
  • Cannabinoids have an effect on nearly all enzymes responsible for metabolizing alcohol. [ S ]
  • CB1 receptor agonists (THC) encourage alcohol consumption, while CB1 receptor antagonists (CBD) decrease it. [ S ]

Although the pharmacokinetics of alcohol and CBD are not yet well-understood, what we do know is CBD inhibits the CYP450 enzyme system, and this system plays a significant role in alcohol metabolism.

Additionally, as found in mice, CBD alters levels of ADH and ALDH to varying degrees.

It is important to be mindful and cautious when mixing CBD and alcohol.

Caffeine and CBD – Better than a PB&J

Caffeine is the world’s most famous and commonly consumed psychoactive drug. Who doesn’t ingest even a little from time to time?

CBD oil is rapidly gaining ground on coffee in terms of popularity and so it only makes sense that people would start combining the two.

As it turns out, the two substances go very well together!

Caffeine is molecularly very similar to adenosine , a compound produced in our bodies that activates the A2a receptor. Caffeine binds to the A2a receptors, inhibiting the reuptake of adenosine.

When adenosine binds to the A2a receptor, the result is what is commonly known as the ‘ rest and digest ’ effect. Consequently, blocking adenosine from binding results in vasodilation , which increases clarity and alertness.

CBD oil is also a partial agonist of the A2a receptor; so the theory goes that by combining caffeine and CBD, adenosine is blocked across the board, resulting in not only more stimulation, but reduced anxiety (due to CBD’s effects on other neurotransmitters systems).

It is worth noting that these effects depend on the serving size of the CBD. High amounts of CBD are more likely to cause drowsiness and sedation.

Additionally, caffeine is metabolized by a CYP450 enzyme, specifically CYP1A2 . As CBD inhibits the CYP450 enzyme system, a slowed excretion rate of caffeine will occur. This can mean the effects of the caffeine will be more prolonged and drawn out. The can be both good and bad!

On the bright side, CBD oil and caffeine together will cause the boost from your morning cup of coffee to last all day instead of just a few hours. On the downside, it’s easy to overdo it and end up wide-eyed in bed when you are trying to go to sleep.

Considering this information, again, it is best to be mindful and cautious when mixing caffeine and CBD.

Can CBD Oil Be Addictive?

One of the most common questions we get is: Can I get addicted to CBD oil? The answer depends on what you mean by “addicted.”

When looking at the chemical impacts of CBD oil, the answer is no. Cannabidiol is not physically addictive in the same way opiates, cocaine, alcohol, and other drugs can be. Also, CBD oil does not produce any physical withdrawal symptoms when you stop using it. In fact, CBD oil is currently being researched as a potential tool for minimizing the severe withdrawal from drugs like opiates.

But, having said that, human beings can get addicted to just about anything including exercise, music, sex, and food.

Because CBD oil can alter essential liver enzymes , it is crucial to do your research, talk to your physician, and figure out how to best consume CBD oil for your specific situation.

Information and education will be your most powerful weapons going forward.

How To Use CBD Oil

When taking cannabidiol, it is important to consume only the recommended serving size.

Raising or lowering this amount may produce the opposite of the desired effect.

Keep in mind that some people may metabolize cannabidiol differently because of anomalies within the cytochrome P45O (CYP450) enzyme system. And depending on when you take your medications, you may find an unintended increase or decrease in CBD concentrations in your blood.

If you suspect that you are not metabolizing CBD oil as expected, ask your doctor to test your cytochrome P450 enzyme system before adjusting your dosage.

Also, you may refer to our page on dosing CBD oil for additional information.

Some of CBD oil's side effects can be dangerous if you do not understand the Cytochrome P-450 System. Discover which drugs are dangerous to combine with CBD.

Cbd oil and methotrexate : Hi, I’ve been taking cbd oil. – NRAS




Cbd oil and methotrexate

Hi, I’ve been taking cbd oil for 4 months and with some of my meds I have to leave a 4-hour gap and 2-hours with others. I started back on methotrexate injections last week, didn’t have my cbd oil that night at hardly slept! Does anyone know how long a gap I need between mtx and cbd oil? Tia xx

  • Methotrexate
  • CBD

Don’t know, I’m thinking there would be very little experience regarding the gap between CBD oil and MTX. I don’t remember reading of someone who’s taking both together

Thanks for your reply xx

This type of problem is going to crop up more often as more people choose to use CBD oil alongside their meds. I don’t think you’ll find the answer on CBD oil sites. You’d need to broach the subject with a medical professional or a pharmacist I would think, you need proper advice. Maybe you could ask your Rheumy. Not wanting to sound preachy but it’s always best to discuss anything you’re considering taking supplement wise with the original prescriber, I’m on MTX & going to ask mine at my appointment in December. My h is already set for his & I’d like to know if it could be something I could dip in & out of when needed, more for my OA than RD though.

Thanks for your reply. My rheumy is fine with me taking cbd oil but didn’t know about the time between meds. She said to ask a pharmacist, who didn’t know. I’ve found the answer from searching on here. Should have done that first 😊 xx

So. Don’t leave us in suspense, what is it?! 🙃

Oh, & where do you buy yours from, if you don’t mind sharing?

Hi, my best advise would be to join CBD users united – UK on Facebook. I told I had RA and sjogrens and what I wanted help with. They advised me to start low and slow. They’ve helped me to choose different oils when I’ve needed to use a stronger one. I started on CBD Brothers green. I would not be where I am today if it wasn’t for the fb group xx

Thank you Mary, that’s just what I wanted to know. Unfortunately though I’m not on Facebook so shall look up CBD Brothers. It does concern me when I read of people just buying canabidiol willy nilly from wherever, not knowing the quality or even if they’re starting on the correct strength. This is why I’ve not dipped my toe yet but that helps.

Can you let me know if there’s any need to leave a gap between MTX & CBD oil. I suspect not but it would be good to know for sure. Thanks again.

Cbd brothers and cheds cdb oils are both reputable sellers. There are more but I don’t know them 😊. I started on cbd bros green oil 1 drop 3 times a day and increased to 2 drops on week 2, 3 on week 3, etc. It’s important to take it slow. I’ve been advised to leave 4 hour before and after my blood pressure tablets and aspirin and 2 hours for other meds. The info I saw said at least 2 hours for mtx, so I will leave 3 hours xx

Thanks again, & for the other seller. If my Rheumy ok’s it I shall go through my other meds with her, just to be sure there are none that are no no’s with it or any others that need spacing. x

Do you know how many mg are in each of the green drops you take and the total per day? I began taking cbd oil 2 weeks ago and it is helping me in more ways than one. Presently I’m taking a 1500mg raw green paste in a syringe, each rice size is 5 mg and I’m splitting it up in 3 doses for a total of 35mg/day. I also am taking methotrexate injections. I have been leaving about 2 1/2 hrs between.

You are so right, we all want to do the best for ourselves. I have been toying with the CBD-oil idea for some time. My GP is ok about his prescriptions, advises seeking clearance from Rheumatologist for my jak-inhibitor; so I’ll do that at my Sept consultation, if not before. Folk talk of specialist suppliers. I would like to know opinions/advice, please, re- the high street: Holland & Barrett sell a selection, in various strengths, off the shelf.

It sounds as though the CBD oil really helps you. what strength do you take ? Has the Rheumy told you any reasons not to take it ? Thanks. – Sorry not on MTX or CDB oil – so cant help on that side of things.

Hi, rheumy is fine about cbd oil. She said quite a few of her patients take it. I’ve worked up to 3 different oils ranging from 4-6%. Cbd oil has helped me with fatigue, insomnia and some pain xx

MadMazzy where do you get it from I need this in my life 😱😱😁

It has been discussed quite a lot janny55, if you check Pinned Posts (top right) there are some there. For more enter CBD oil in the Search Healthunlocked box & under Filter results – Posted in – View more & select NRAS & more will appear.

Thank you nomoreheels will be having a look 👀😁

Hi, I’ve been looking into this a lot as I’d like to try it, haven’t taken the plunge yet! There is a site called cbd brothers which gives a bit of info and also one called Simple?

I’ve joined a couple of fb groups and there’s lots of info there too.

Ooooh thanks Sjhoney I know I would love to try it but a bit scared 😱🤗 good luck too let me know if you take the plunge 👍😁x

Hi, see my reply to nomoreheels, best to join the Facebook group. There are a lot of unscrupulous people out there, willing to take your money for poor products xx

Thanks MadMazzy will have a look 👀 😁👍x

There just isn’t enough evidence based research yet. As more people combine CBD and MTX there will be more research available.

I did find this though:

Thank you for sharing experiences (which are the closest thing to research: case studies) and for asking this question.

Hi, I’ve been taking cbd oil for 4 months and with some of my meds I have to leave a 4-hour gap and 2-hours with others. I started back on methotrexate injections last week, didn’t have my cbd oil… ]]>