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Can you have an allergic reaction to CBD oil?

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Contents

  1. CBD oil overview
  2. Allergies in the body
  3. Allergic reactions to CBD oil
  4. Can CBD oil help with allergies?

Whether it’s sniffling, watery eyes, itching, or asthma, many of us are all too familiar with symptoms of allergies.

According to the Asthma and Allergy Foundation of America, allergies are the No. 6 cause of chronic illness in the United States. To narrow that down,there were 19.9 million adults diagnosed with hay fever in 2017, according to the Centers for Disease Control and Prevention (CDC). It is estimated that 32 million Americans live with food allergies; more than 170 foods may lead to allergic reaction.

Considering the increasing awareness and use of cannabidiol (CBD) and the existing potential for pollen and food allergies, allergy sufferers may wonder whether they are at risk for an allergic reaction to CBD oil or whether CBD can provide treatment or relief for other types of allergic reactions.

Though there’s not much in the way of allergy research specifically for CBD oil at this point, the cannabis plant itself has been linked to allergic reactions.

“Marijuana is a plant and produces pollen and one can become allergic to the pollen and the plant, especially if one has pre-existing allergic tendencies,” said Dr. William S. Silvers, clinical professor of medicine in allergy and immunology at the University of Colorado School of Medicine.

That being said, only male marijuana plants produce pollen, and are exceedingly rare in cannabis and hemp production because they produce less oil and CBD than female plants. Therefore, a consumer’s exposure to pollen would be extremely rare.

CBD oil overview

CBD is the second-most-prominent cannabinoid derived from the cannabis plant, after the intoxicating cannabinoid THC. CBD oil, extracted from marijuana or industrial hemp, has gained popularity for its potential benefits for a number of conditions, including inflammation, arthritic pain, depression, seizures, and anxiety.

There’s not much in the way of allergy research specifically for CBD oil, but the cannabis plant itself has been linked to allergic reactions in some people. Photo by: Gina Coleman/Weedmaps

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Though research is still limited in regards to many supposed benefits, in 2018 the FDA approved Epidiolex, a CBD oral solution, to treat seizures associated with two severe types of epilepsy, Dravet syndrome and Lennox-Gastaut syndrome.

Allergies in the body

A properly functioning immune system works to protect the body from pathogens such as bacteria, viruses, and fungi, and attack these unwanted microorganisms in order to help prevent disease. In the case of allergies, the immune system reacts to plant pollen and other substances in the environment to trigger the body’s defense mechanisms. The result, depending on the type of allergy, can be a variety of symptoms, including itchy eyes, runny nose, asthma, hives, skin itching, or more severe reactions such as anaphylaxis, which can be life-threatening.

Allergic reactions to CBD oil

Humans commonly experience allergic reactions to many kinds of plant pollen. However, only male cannabis plants produce pollen, whereas female plants are more widely used for oil and cannabinoid production. Large-scale industrial hemp fields may include a variety of mature males (pollen) as well as fertilized females (oil and seeds). The impact of hemp pollen on everyday consumers, as well as the communities that work and live near these production facilities, has not been studied.

People can also develop allergies to some of the terpenes found in cannabis. For instance, researchers from the Duke University School of Medicine found that about 20% of the 100 people they tested had an allergic skin reaction to linalool, whereas 8% had reactions to limonene. These kinds of contact allergies may not be common in the general population, but individuals who are employed in the production of cannabis products and CBD oil could be more at risk.

In addition to the skin, the lungs are another target for allergic reactions to terpenes. Assessing the risk is somewhat complicated because some terpenes are irritants, whereas others, such as eucalyptol, may actually provide a protective, anti-inflammatory role and might help to control inflammatory diseases like asthma and COPD.

Dr. Gordon Sussman, an allergist in Canada and professor at the University of Toronto, said there is very little published research on CBD oil allergies.

“It’s an unknown area at this point,” he said. “But we know that cannabis sativa is an allergen and we know that it’s a common allergen.”

Humans commonly experience allergic reactions to many kinds of plant pollen. Only male cannabis/hemp plants produce pollen. Most cannabis products, including CBD oil, are made using female cannabis plants. Photo by: Gina Coleman/Weedmaps

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He said that cannabis allergies, like other forms of allergies, can worsen as exposure to the allergen continues. Most people with cannabis allergies suffer from a runny and stuffy nose (rhinitis), eye irritation (conjunctivitis), and sometimes wheezing, Sussman explained. But there have been cases of more severe reactions such as anaphylaxis, which have primarily resulted from ingestion of hemp seeds.

According to a letter entitled “Marijuana and stoned fruit,” written by medical doctors from the University of California, San Diego, and published in the Annals of Allergy, Asthma, and Immunology on Feb. 2, 2018, a 24-year-old man who smoked marijuana daily visited their allergy clinic two weeks following an anaphylactic reaction after eating yogurt with hemp seeds.

“This was his first known ingestion of hemp seeds. Immediately after consumption, he developed oral pruritus [itching] that progressed to shortness of breath, facial swelling, and pre-syncope [sensation prior to fainting],” the letter stated.

Those with food allergies may also be susceptible to cross-reactivity.

“You can have a cross-reaction with certain foods that share certain antigens, certain components, with the cannabis plant itself,” Silvers said.

Such foods may include tomatoes and stone fruits containing pits such as peaches, he said. It’s a similar cross-reactivity to what is seen in people with ragweed allergies who might experience symptoms such as itchy mouth if they eat fruit in the melon family, he added.

“The same thing goes with cannabis and tomatoes and peaches and almonds and a number of other foods … eggplant, grapefruit, apples,” Silvers said.

There is no clinical evidence CBD oil can help allergies. Photo by: Gina Coleman/Weedmaps

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A 2013 study from the “Internal Archives of Allergy and Immunology” tested 21 patients with food allergies for reactivity to cannabis lipid transfer proteins (LTPs), which are probable allergens. Twelve of the 21 test subjects were allergic to cannabis, and all 12 had more severe reactions to food allergy than those without a cannabis allergy. A 2008 study, also from “Internal Archives of Allergy and Immunology,” tested 32 subjects for an allergic reaction to cannabis LTPs, as well as tomato, peach peel, and pollen extracts. The study found that all test subjects sensitive to tomato allergens were also sensitive to cannabis. There was also cross-reactivity noted with peach peel.

Silvers said that the type of allergic reaction depends on the type of exposure. In addition to cannabis pollen allergies and food-based allergies, skin allergies are also a possibility.

“Touching the plant can very easily develop a dermatitis, itching, and skin reactions,” he said.

Can CBD oil help with allergies?

While there isn’t much research supporting the idea that CBD oil can help the discomfort associated with common allergy symptoms, there is some research related to its general effects on inflammation, which is part of the body’s allergic reaction process.

A 2011 research report published in the journal Free Radical Biology and Medicine examined the potential role of CBD in various inflammatory-type conditions. George W. Booz, a professor in the department of pharmacology and toxicology at the University of Mississippi Medical Center, concluded in the report: “Inflammation and oxidative stress are intimately involved in the genesis of many human diseases. Unraveling that relationship therapeutically has proven challenging, in part because inflammation and oxidative stress ‘feed off’ each other. However, CBD would seem to be a promising starting point for further drug development given its antioxidant (although relatively modest) and anti-inflammatory actions on immune cells … .”

According to Silvers, there is no clinical evidence CBD oil can help allergies and, while experimental laboratory research suggesting anti-inflammatory effects exists, there’s no clinical patient substantiation.

Can you have an allergic reaction to CBD oil? Copy article link to clipboard. Link copied to clipboard. Contents CBD oil overview Allergies in the body Allergic reactions

CBD for Allergies?

Does CBD have the same effect as antihistamines?

Nikki Tate
May 25, 2019 · 4 min read

When I got on the plane ten days ago on my way from Alberta to the coast, my first thought when I settled into my seat and buckled my seatbelt was, “Damn! I forgot my allergy meds!” My seasonal pollen allergies are debilitating, at least when I’m on the coast.

For several months, in some years starting as earl y as late February and lasting until August, swollen, itchy eyes, runny nose, and a scratchy, swollen throat made my life miserable. When things got really bad, my eyes would swell shut and I’d look so dreadful small children would look away when they saw me.

In the mountains, the pollens are different and my symptoms are pretty much non-existent. Plop me back on the coast at this time of year, though, and it only takes a few hours before I’m grinding my fists into my eyes and (almost) longing for the return of winter.

If you’ve been reading my posts for a while, you’ll know that about a month ago I was given a prescription for CBD oil to help manage pain in my arthritic hip while I wait for hip replacement surgery. (If you missed that story, the link’s below).

One Good Night Does Not a Randomized Trial Make

But wow — one dose of CBD oil and I’m a believer!

medium.com

All week, I was half expecting a flare-up on the allergy front, but I was totally symptom-free until yesterday when my son-in-law attacked the yard and some tall grass with the weedwhacker. Pollen floated everywhere and, sure enough, I felt that old familiar eyeball itchiness… That was the moment when it occurred to me that it might have been the low CBD dose I’ve been taking each evening before bed that had been holding the allergy symptoms at bay.

Rather than reaching for my usual default oral antihistamine (the backup plan without the potent prescription allergy meds I’d forgotten back in Alberta), I took some CBD oil. A few drops under the tongue and within about ten minutes, no more itchy eyes!

I just checked the allergy rating on my weather app and here in Victoria the grass pollen rating is HIGH. This morning I took another small dose of CBD and remain symptom-free. This, of course, sent me off to the land of Google to see what I could find out about CBD and allergies.

CBD Oil and Allergy Relief

CBD is known to have anti-inflammatory properties, so it makes sense that when the sensitive tissues around the eyes get agitated, then a dose might help calm things down.

Though there’s limited research available, it seems that cannabinoids may act on mast cells (the cells responsible for releasing histamines in an allergic reaction) in a similar fashion to antihistamines. In the past (for me), traditional antihistamines were extremely effective for the first few doses but quickly lost their potency and were basically useless after about a week of regular use. This is why we had to ramp up control efforts and each spring I’d have to use a steroidal nasal spray. While that was very effective, I wasn’t all that keen on having to take anything with steroids for several months each year.

I have no idea whether this same diminishing returns effect would occur with CBD oil and, as I’m leaving today to head back to the much less aggravating (in a pollen-esque sense) atmosphere of the Rocky Mountains, I won’t be able to provide more information. However, it would seem that in the short term at least, a few drops of oil under the tongue have shut down whatever ‘oh-my-lord-pollen. ’ reaction my immune system was considering.

Note: I am NOT a medical person of any kind. Just reporting my observations and contributing to the conversation in case this might be a discussion you want to have with your physician. As per my earlier post — see link above — I’ve embarked on this CBD experiment on the advice of three different physicians and was somewhat skeptical when I began.

I am curious to hear about the experiences of others, so if you have tried CBD for allergy relief, how did it work for you?

When I got on the plane ten days ago on my way from Alberta to the coast, my first thought when I settled into my seat and buckled my seatbelt was, “Damn! I forgot my allergy meds!” My seasonal…