cannabis pineal gland

How Cannabis Affects The Pineal Gland

The pineal gland has a profound impact on the brain. Its sensitivity has led to speculation that it is the “third eye” referred to in mythology. It is worth investigating what sort of impact cannabis has on this part of the brain.

“The third eye” appears as an iconic symbol in Ancient Egyptian art. The Hindus also symbolised a third human eye with a ceremonial red dot or “bindi” on the forehead. This is said to mark the location of the Ajna chakra, a centre of energy for the subconscious mind. It is said to be humanity’s link to the spiritual realm, with philosopher René Descartes calling it “the seat of the soul”. Wasn’t much of Descartes’ medical research roundly discredited even during his lifetime? In short, yes. However, the long answer allows for the nuance that chakras do appear to correspond to important physiological locations throughout the body.

In the case of the third eye, the pineal gland not only appears there as an important neurological organ; it is in fact a light-sensing organ structurally similar to the eye. Okay, maybe there is something going on here. The pineal gland is important to many disparate cultures for its spiritual significance. It is named for its pinecone shape, a symbol that appears throughout the art of Assyrian, Greek, and other cultures. Claims about its powers range from attuning one’s mind with God or even telepathic communication. Let’s look at what the science has to say about the powers of the pineal gland. If it does serve some important function, then it is also worth exploring how cannabis can impact this part of the brain.


The first thing to look at is this whole “third eye” thing. Is it actually that similar to the eyes we see with? Or could it be some vestige of an eye that was previously there? Or has yet to fully evolve? Slow down. Let us consider how the name “pineal” relates to the gland’s pinealocytes. These are cells that respond to light. They are connected to the hypothalamus of the brain. This is where the governance of our circadian rhythm, or sleep-wake cycle, comes from. The hypothalamus communicates the presence of darkness to the pinealocytes, forming part of human perception of day and night. So it does form an important component of human perception. In other animals, it is even directly connected to the eye.

Many vertebrates across the mammal, reptile, and fish kingdoms have evolved a pineal gland. Others have evolved not to have one. In the case of the New Zealand reptile the tuatara, the pineal gland is directly connected to a literal third eye! Technically, the parietal eye is the correct gland to call a third eye. This gland appears on the tuatara’s head with a lens, retina, and cornea of its own. This connects to the pineal gland, as do the glowing third eyes of various deep-water fish. From an evolutionary standpoint, the pineal gland is clearly important to circadian rhythm, hormonal regulation, and things like that. But what else does it do for humans? And how would it be affected if said humans enjoyed some cannabis?


The pineal gland receives blood flow directly from the rest of the body through the posterior cerebral artery. Since the blood is not processed through the blood-brain barrier, psychoactive chemicals hit the pineal gland much quicker. This makes it very sensitive to psychoactive chemicals such as DMT or cannabinoids. The pineal gland regulates healthy sleep through the production of melatonin. This is an important function to not mess up. Overconsumption of cannabis, as the definition of “excess” suggests, could have an adverse impact on this and other aspects of your health. It’s safer to moderate your cannabis use. If you are using cannabis, what can you expect to happen to the pineal gland?

The pineal gland is connected to the endocrine system and the endocannabinoid system. So as part of the network of cannabis’ influence, it helps the flow of cannabinoids to cannabinoid receptors. Perhaps your trippy dreams are the impact of cannabinoids regulating the depth and duration of your sleep. It has been suggested THC may reduce melatonin, which would adversely affect sleep. Yet so many people use cannabis to help get to sleep. Other effects of cannabis relieve worries and physical tensions that hamper sleep. The science around the relationship between cannabis and sleep requires further study.


Whether or not cannabis boosts some spiritually significant function of the pineal gland is down to perspective. An altered state of consciousness can be triggered by activity of the pineal gland during meditation. Meditative and psychedelic states are also known to arise through cannabis use. Cannabis has been used as a sacrament in far-flung religious ceremonies from Hinduism to Rastafari. There can be profound feelings of personal insight or connectedness with the world when taking cannabis. Does this sense of contentment come from the underestimated power of opening our third eye and stimulating the pineal gland? Or is this just the way one thinks when high? Stoners have a range of beliefs from the spiritual to the sceptical. Therefore, each person’s experience will vary. One thing we can all agree on is our fascination with the power of cannabis.

The pineal gland is said to be the third eye of mythology, but how does it interact with psychoactive cannabis?



Why has the pineal gland fascinated humanity for eons? René Descartes, dubbed the inventor of western philosophy and elite scientist, believed the pineal gland to be the principal seat of the soul.

“Is the pineal gland the seat of spirituality and consciousness, is it the site of the primordial “third eye”, is the pineal gland encaptured by the Egyptians in their statues and artwork? There is a lot of evidence, both from the ancients and modern researchers that the pineal gland is responsible in large part for the activity or effects of psychoactive drugs.”


The Pineal gland is responsible for producing and releasing melatonin. Melatonin is normally released when there is near total darkness and release stops when there is light. The day-night cycle is called circadian rhythms. Smooth and uninterrupted circadian rhythms are fundamental to proper body and mental function. Another substance that is postulated to be produced in the pineal gland is pinoline, whose most outstanding pharmacological properties is its ability to promote neurogenesis.

“A basic goal of medical practitioners should be; to find the right mixture of cannabinoids and other natural medicinals that balances the function of the brain – the hypothalamus and pituitary gland – that re-balances their natural function.”

THC, marijuana’s most common active ingredient has been shown to cause anxiety in some patients, but when THC is given with cannabinoids (like CBD) and terpenes it works in synergy to produce more sedative effects. Together, their action may stimulate the pineal gland to release melatonin.



When THC is combined with the terpene Myrcene, THC is more sedating and acts as a muscle relaxant. Studies also show the mixture (found naturally in several strains) potentates sleep time, which p\helps people stay asleep. Though all the science is not yet in, this effectively explains “couch-lock,” a feeling reported by many a user. Couch lock is actually a useful therapeutic effect for those that are too highly strung and have a problem unwinding. ther cannabis terpenes that contribute to relaxation and sleep are nerolidol, linalool and limonene.

Cannabis cannabinoids not only appear to help regulate circadian rhythms, but also bodily rhythms such as cardiac rhythms and racing of the heart.


As far as western medicine is concerned, the primary function of the pineal gland is to produce melatonin. Melatonin performs several functions in the central nervous system, the most important modulating sleep patterns. Melatonin release is inhibited by light and stimulated by darkness. Light sensory nerve cells in the retina detect blue light and send a signal to the suprachiasmatic nucleus.

“Forget everything else. Imagine if you felt good mentally most of the time, and you had the power to control your emotions and behavior how you want. What kind of person would you be? And what kind of success would you have?”


Modern Science agrees ancient writing, the pineal gland is a driving force behind your character, if not your soul, marijuana has been found to play a very similar role bio-chemically.. Cannabis has been shown to show efficacy in neuroregeneration, sleep disorders, stress, appetite for food and sex, all of which parallel the functions of the hypothalamus and pineal glands. Recently, researchers are discovering how phyto-cannabinoids and other components of the marijuana plant, interplay and balance (or imbalance) this heart and soul command center of the brain.

The suprachiasmatic nucleus – SCN is a tiny region of the brain in the hypothalamus (brain), situated directly above the optic chiasm which is connected to the eye (retinal nerves) contains only 20,000 neurons. It is responsible for controlling circadian rhythms over the 24-hour cycle. The neuronal and hormonal activity of the SCN regulates many different body functions. The SCN interacts with other regions of the brain and has several cell types that produce different peptides such as the hormone vasopressin, vasoactive intestinal peptide and neurotransmitters.

It is important to synchronize the SCN to the day-night cycle. Nerve fibers then relay retinal activation (to blue light) from the SCN to the paraventricular nuclei or PVN.

The paraventricular nucleus is a nucleus in the hypothalamus (brain) where its neurons are activated by physiological changes including stress. The PVN neurons project directly the pituitary where oxytocin is released into the blood. Oxytocin has hormonal) action, and acts on the brain. There is a oxytocin receptor that requires magnesium and cholesterol to work properly. Oxytocin’s has a role in behaviors, including orgasm, social recognition, pair bonding, anxiety, and maternal behaviors. Other neurons in the hypothalamus – pituitary-system are involved directly in the regulation of appetite and autonomic functions in the brainstem and spinal cord.


Studies on rodents find that pineal gland probably influences the secretion of the sex hormones, hair follicle-stimulating hormone, and luteinizing sex (testosterone) hormones.

Studies on rats suggest that the pineal gland probably interacts with recreational drugs and that its hormone melatonin protects against neurodegeneration. Recreational drugs which interfere with the activity of the pineal, like cocaine and other hard drugs is conjectured to cause significant misbehavior.

Studies in mice suggest that the pineal-derived melatonin regulates new bone deposition, which is consistent with the observed bone stimulating growth of CBD, the second most common phytocannabinoid of marijuana. Pineal-derived melatonin mediated action on the bone cells through MT2 receptors. This pathway could be a potential new target for osteoporosis treatment.

Pinoline has long been claimed to be produced in the pineal gland during the metabolism of melatonin. Pinoline is a free radical scavenger, an antioxidant.

One of pinoline’s pharmacological properties is its ability to promote neurogenesis in vitro; even at trace concentrations in common with several cannabinoids like THC and CBD. Further study is required to firmly establish the exact mechanism of synergy between cannabis components, but the scientifically grounded implications is there in spades.

Aluminium toxicity causes lipid peroxidation damage in the brain. A recent review of studies shows both pinoline and melatonin to be effective at reducing the lipid peroxidation. If cannabinoids can be shown to elevated these brain chemicals to optimal levels, then their efficacy is obvious.

Lipopolysaccharide produced by bacterial infection stimulates the production of free radicals, which cause lipid peroxidation. Melatonin and pinoline were demonstrated in the ability to reduce lipid peroxidation damage. Pinoline was also shown to be better than vitamin E in reducing lipopolysaccharide activity in the retina, yet another overlap with cannabis, which is well known for its ability to combat glaucoma.

Lipopolysaccharides composed of a fat and sugar(s). and are found on the membrane of bacteria, which cause strong immune responses. These rogue fat-sugars may hold a key to inflammation and autoimmune disorders. Cannabinoids have the ability to control or reduce inflammation in many disorders, and interfere with the reproduction of common pathogenic bacteria (gram-negative). This is yet another avenue where cannabinoids and the “melatonin system” may work together to combat autoimmune disorders.


According to the most bland mainstream science, the pineal gland is sensitive to all magnetic fields, including geomagnetic fields of the Sun’s solar storms. The pineal gland is also sensitive to tissue calcification, especially when combined with rogue forms fluoride, i.e. water and toothpaste additives. Calcification of the pineal is thought to be a major cause of mental disorders and behavioral aberrations.

Combine these facts and observations with the modern diet rife with artificial calcium chemical additives, many of which cannot be assimilated properly in the body. Worse yet, calcium rich milk and dairy products are generally not assimilated well by adults and are implicated in calcium deficiency, osteoporosis and deposits in the arteries and brain tissues.

” The pineal regulates our conscious awareness.” – Rene Descartes,


This chapter about the mysterious and awesome Pineal cannot close without reference to its place among the elite and their symbolism. The pineal gland figures big in the conspiracy theories about the shadow government, the Bilderbergers, the Illuminati, Queen of England, ancient Egypt and onto Babylon. The imagery-worship or whatever of the pineal is incredible and begs the question, WTF?

“Brain scans reveal that pineal activity increases with meditation, with some alternate thinkers believing that certain frequencies can stimulate the pituitary and cause a sense of euphoria and connect one with the universe.”

The latest conspiracy theory has Bilderberg – the leaders of government, banking, mega-corporations, discussing the future implications CERN – a multi-billion dollar particle accelerator, which might open up a door to an extra dimension. Out of this door might come something, or we might send something through it, reports ”

MMJDoctorOnline Notes: Before 2018, a licensed physician’s recommendation for medical marijuana is required to purchase cannabis from any California or Nevada Dispensary. A 420 evaluation can be completed entirely online. This process takes minutes to apply for either a Cannabis ID Card, a medical permit for marijuana (recommendation) or a grower’s permit. Renewals can be processed for conditions and symptoms that remain from the previous year.

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Research on rats has shown that the pineal gland contains a functional endocannabinoid system, in that cannabinoid receptors type 1 and 2, and the endogenous ligands that bind to them, anandamide and 2-AG, are all present.

The study showed that the activity of the CB?-receptors varied according to a daily cycle, with lowest activity levels occurring at the end of the daylight period. It also showed that levels of an enzyme responsible for synthesizing new endocannabinoid molecules, NAPE-PLD, was reduced during the middle of the dark period.

Furthermore, the study showed that presence of THC reduced the activity of an enzyme known as AANAT, and in doing so reduces the synthesis of melatonin itself. An earlier study on rats also showed that THC reduced the activity of AANAT, and suggested that the mechanism that occurred was as follows: the neurotransmitter norepinephrine starts a cascade of reactions, the end result of which is the production of melatonin. THC disrupts this norepinephrine cascade and thereby reduces the production of melatonin.

Carded CERN scientists busted for weird ritual.

Psychedelic researcher Dr Rick Strassman explains:

“The pineal gland is quite active in synthesizing compounds related to serotonin, an important neurotransmitter in the brain. Neurotransmitters are the chemical messengers allowing communication among individual nerve cells. Most typical psychedelic drugs, such as LSD, mescaline, psilocybin, and DMT are active in brain sites which are also affected by serotonin.”

“Psychedelic drugs, meditational states, spontaneous near-death experiences and other phenomena which may induce stereotypic death/rebirth and paradisal/hellish states act via the pineal gland.”

Cannabis or Marijuana among other psychedelics facilitates the activation of the pineal gland and helps turn on the third eye or the mind’s eye directing our spiritual evolution to wholeness. The pineal gland, located in the centre of the brain, is about a quarter of an inch in size, reddish-gray, and weighs about one-tenth of a gram. Unlike other parts of the brain which

In a yogic or shamanic state of consciousness, marked by high theta brain wave activity (an often induced by meditation, drum playing with a steady beat of four and one-half times per second, or with binaural beats meant to entrain the brainwaves for theta activity) we can access a ‘trance’ state which is more likely to come from an opened pineal gland and result in feelings of absolute bliss.

“Theta waves have been identified as the gateway to learning and memory. Theta meditation increases creativity, enhances learning, reduces stress and awakens intuition as well as other extrasensory perception skills. Through theta wave meditation, we can open our Third Eye and access the delta waves that unite us with Universal Energy and Cosmic Consciousness.”

Forget everything else. Imagine if you felt good mentally most of the time, and you had the power to control your emotions and behavior how you want. What ki